grant

News

Open trials

Work continues on collecting follow-up data for the RCHOP14 vs 21 trial and the primary outcome results are to be presented at the American Society of Haematology (ASH) Annual Meeting in December 2010. This trial has recruited more than a 1,000 patients from over 100 hospitals in the UK.

The Independent Data Monitoring Committee has encouraged us to publish the results of the Watch and Wait trial as soon as possible, and ought to be submitted to the ASH meeting in December.

Closed trials

The LY02 paper (‘Final analysis of the UKLG LY02 trial comparing 6–8 cycles of CHOP with 3 cycles of CHOP followed by a BEAM autograft in patients <65 years with poor prognosis histologically aggressive NHL’) was published in the British Journal of Haematology on 1 March 2010.

The Radiation Dose trial was submitted to the Journal of Clinical Oncology and is currently being worked on to address the reviewers and editorial comments prior to resubmission.

The FMD vs CMD and LY07 trial have yet to be submitted for publication but we remain committed to getting them published as soon as possible.

Follow-up

Discussions are continuing with the National Cancer Intelligence Network (NCIN) about how best to collect long term follow-up for trial patients. The NCIN has access to hospital and GP data on millions of patients but it is currently incomplete (i.e. most data are only currently available for England and GP data is only available on 13 million people at present). This means that the Lymphoma Trial Office will need to continue to collect data for the foreseeable future.

New trials

No new lymphoma trials have opened since the last report but two new trials are being developed for patients with Waldenstroms Macroglobulinaemia in conjunction with the NCRI myeloma subgroup.

New grants awarded (Jan 2010)